Electrophysiological study of human heart muscle.
نویسندگان
چکیده
• Attempts to record membrane potentials from the human heart exposed during surgery have been reported by Woodbury et al. and Bromberger-Barnea et al. In these studies, rather large variation in the amplitude and time course of the potentials was observed, perhaps related to the circumstances of working with flexibly mounted micro-electrodes on an exposed, contracting heart. The present experiments were undertaken on the strength of the evidence that records obtained from suitably prepared and maintained tissue preparations excised from other mammalian hearts do not differ from records made in situ.4 Membrane potential changes of small preparations of human ventricular and atrial tissue, excised during open-heart surgery, were recorded in vitro, and the effects of physical and chemical influences on the resting and action potentials of single myocardial fibers were studied to test whether the basic concepts of the mechanisms underlying the action potential, automaticity and transmitter effects, derived from investigation of other cardiac tissue, are applicable to the human heart.
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عنوان ژورنال:
- Circulation research
دوره 10 شماره
صفحات -
تاریخ انتشار 1962